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A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output.Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures. It was developed by Daniel Bovet in 1947. The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.Gallamine is a tertiary amine non-depolarising muscle relaxant whose structure comprises a core benzene molecule substituted at each of C-1, C-2 and C-3 by an N,N-diethyl-2-(ethylamino)ethoxy group. It has a role as a muscle relaxant, a cholinergic antagonist and a drug allergen.
Description: Gallamine Triethiodide is a mAChR M2 antagonist with pronounced cardioselectivity. It acts by combining with the cholinergic receptor sites in muscle and competitively blocks the transmitter action of acetylcholine. It is a synthetic non-depolarizing blocking drug.A synthesis essay thesis serves as the main argument of the entire paper. It is a full sentence or few sentences that identify the academic essay on a chosen topic in a significant manner. It is like a background of the whole paper. A thesis should be as impressive as an essay title.
This was the precursor to much of the work on neuromuscular blocking drugs that took place after the Second World War. The turn of the century heralded several momentous developments. In Great Britain, Sir Henry Dale and colleagues working at the National Institute of Medical Research established the role of acetylcholine and the chemical basis of neuromuscular transmission 9.
